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Yuan et al., 2019), the engineered protein eNK1, created by the disulfide-linked NK1 (N-terminal and the K1 first kringle) domains of HGF (Liu et al., 2014), a novel dimeric form of the K1 domain, designated K1K1 (Vallarola et al., 2020), the semi-synthetic engineered K1 domain, designed to be multimer by biotin-avidin interaction (Simonneau et al., 2015), a MET-agonistic DNA aptamer (Ueki et al., 2016, 2020), and MET-agonistic synthetic macrocyclic peptides (Sato et al., 2020)
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Mitochondria are highly enriched in hepatocytes and are the central hub of cellular metabolism through the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation that produces ATP